在美国成年人中暴露于阻燃剂和牛皮风险之间的关联:基于人口的研究
Jingbo Zhang1, Xiangyun Shi2, Genlong Bai1
1Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
Ecotoxicology and environmental safety
|February 7, 2025
概括
暴露于制阻燃剂 (BFRs) 与患牛皮的风险更高有关. 具体来说,多化双153 (PBB153) 显示了与成年人牛皮发病率的显著,非线性关联.
科学领域:
- 环境健康 环境健康
- 皮肤病学 皮肤病学
- 毒理学 毒理学 毒理学
背景情况:
- 牛皮风险受到环境化学物质暴露的影响.
- 制阻燃剂 (BFRs) 对牛皮的特定影响仍未得到充分研究.
研究的目的:
- 调查暴露于六种BFR化合物与自我报告的牛皮风险之间的关联.
- 确定导致牛皮风险的特定BFR,并描述它们的剂量反应关系.
主要方法:
- 国家健康和营养检查调查 (NHANES) 数据 (2003-2014) 的分析,来自6340名成年人.
- 应用统计模型,包括多变量逻辑回归,受限制的立方线 (RCS),加权量子和 (WQS) 回归,基于量子的g计算 (Qgcomp) 和贝叶斯核心机器回归 (BKMR).
主要成果:
- 同时暴露于BFR与增加牛皮风险显著相关.
- 聚二153 (PBB153) 被确定为导致牛皮风险的关键因素.
- 在血清PBB153度和牛皮的患病率之间观察到非线性关系,在性别子组之间一致.
结论:
- 这项研究提供了强有力的证据,将BFR暴露与牛皮的患病率联系起来.
- PBB153是牛皮的重要环境风险因素.
- 对BFR和牛皮的机制和政策干预措施的进一步研究是有必要的.
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