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相关概念视频

Cellulose and Pectic Polysaccharides01:15

Cellulose and Pectic Polysaccharides

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 Every plant cell has a cell wall that protects the cell, provides structural support, and gives the cell shape. Cellulose, the main structural component of the plant cell wall, makes up over 30% of plant matter. It is the most abundant organic compound on earth.  Cellulose is an unbranched polysaccharide composed of linear chains of glucose molecules linked by β (1→4) glycosidic bonds.
As a cell matures, its cell wall specializes according to its type. For example, the...
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Cell Adhesion in Plants01:14

Cell Adhesion in Plants

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Plants have rigid cell walls that are made up of cell wall polysaccharides that mediate cell-cell adhesion. The primary cell walls of plants consist of two independent and interacting polysaccharide networks: a pectin matrix that embeds the second network comprising cellulose and hemicelluloses.
Pectins are complex heteropolymers mainly composed of negatively-charged α-D-glucopyranosyl uronic acid and some neutral glycosyl residues such as α-L-rhamnopyranose, α-L-arabinofuranose,...
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Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

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Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
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Factors Influencing Drug Absorption: Physicochemical Parameters01:22

Factors Influencing Drug Absorption: Physicochemical Parameters

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The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
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Factors Affecting Dissolution: Drug pKa, Lipophilicity and GI pH01:21

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Drug absorption within the gastrointestinal (GI) tract is a complex process influenced by several critical factors, including the site pH, the drug's dissociation constant (pKa), and the drug's lipophilicity. The GI tract exhibits a pH gradient, with an acidic environment in the stomach and a more alkaline environment in the small intestine. This pH variation directly affects the ionization state of drugs.
A drug's pKa and the pH of the gastrointestinal (GI) tract play crucial roles...
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Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

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Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
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相关实验视频

Updated: May 29, 2025

Structural Characterization of Mannan Cell Wall Polysaccharides in Plants Using PACE
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Structural Characterization of Mannan Cell Wall Polysaccharides in Plants Using PACE

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:结构特征,ADME概况及其相互关系.

Haizhao Song1, Yanhui Zhang1, Fang Wang1

  • 1College of Food Science and Engineering/Collaborative Innovation Center for Modern Grain Circulation and Safety/Key Laboratory of Grains and Oils Quality Control and Processing, Nanjing University of Finance and Economics, Nanjing, China.

Chemistry & biodiversity
|February 7, 2025
PubMed
概括

是一种植物多糖,由于其独特的结构,它提供了有价值的食品和制药应用. 这篇评论探讨了乳清素的研究.

关键词:
吸收 吸收 吸收 吸收和分泌 (ADME) 概况.生物可用性 生物可用性分销 销售 分销 销售 分销 销售提取 提取 提取 提取代谢过程中的代谢.修改的意思是改变的意思.乳清素 (pectin) 是一种可怕的物质.结构 结构 结构 结构

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相关实验视频

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Experimental Screening Protocols, Immunocytochemistry and Microscopy-based Imaging Techniques for Penium margaritaceum
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科学领域:

  • 食品科学 食品科学 食品科学
  • 生物化学 生物化学
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 是一种多用途的植物多糖,因其凝,加厚和稳定功能的原因,在食品和制药行业广泛使用.
  • 它的特性与其结构特征密切相关,特别是甲基化 (DM) 的程度和关键成分的存在,如homogalacturonan (HG),rhamnogalacturonans (RG-I) 和RG-II.
  • 了解pectin的结构-功能关系对于优化其应用至关重要.

研究的目的:

  • 提供关于pectin的结构,提取方法及其对功能的影响的全面审查.
  • 批判性地检查的吸收,分布,新陈代谢和分泌 (ADME) 概况.
  • 要突出新兴的研究方法,并确定未来的研究方向的应用.

主要方法:

  • 文献综述重点关注点的结构,提取技术 (例如,亚临界水,微波辅助) 和ADME研究.
  • 分析结构参数 (分子量,DM,中性糖) 如何影响pectin的生物可用性和肠道微生物群相互作用.
  • 探索新的研究方法,以获得药理动力学见解.

主要成果:

  • 不同的提取方法极大地影响了pectin的结构和功能性质.
  • 的结构属性,包括分子量和DM,决定了它的ADME配置文件和与肠道微生物群的相互作用.
  • 新兴的研究技术为pectin的药理动力学行为提供了新的视角.

结论:

  • 的复杂结构和提取方法是其功能和生物可用性的关键决定因素.
  • 素在功能性食品,个性化营养和向治疗中表现出显著的潜力.
  • 需要进一步的研究,以充分阐明pectin的药理动力学特性,并优化其治疗应用.