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Updated: May 29, 2025

Studying DNA Looping by Single-Molecule FRET
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Published on: June 28, 2014

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对DNA序列特异性识别的替代方法:协同堆叠语法维度――对化合物曲率,芳香结构和DNA序列的敏感性

Ananya Paul1, J Ross Terrell1, Abdelbasset A Farahat1,2,3

  • 1Department of Chemistry and Center for Diagnostics and Therapeutics Georgia State University, Atlanta, Georgia 30303, United States.

ACS chemical biology
|February 7, 2025
PubMed
概括

研究人员设计了新的小分子,可以选择性地结合到特定的DNA序列,特别是TTAA位点. 这一突破推动了基因表达调节,并通过准DNA小沟相互作用,提供了潜在的治疗应用.

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