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Updated: Aug 6, 2026

Detection of Protein Palmitoylation in Cultured Hippocampal Neurons by Immunoprecipitation and Acyl-Biotin Exchange ABE
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Detection of Protein Palmitoylation in Cultured Hippocampal Neurons by Immunoprecipitation and Acyl-Biotin Exchange ABE

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纳米体-thioesterase 嵌合体专门针对蛋白质棕化

Chien-Wen Kuo1, Caglar Gök1,2, Hannah Fulton1

  • 1School of Cardiovascular & Metabolic Health, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.

Nature communications
|February 7, 2025
PubMed
概括

研究人员开发了纳米体酶嵌合体,以精确控制蛋白质翻译后修饰 (PTMs). 这种方法允许针对性地操纵PTM,在疾病研究和临床环境中提供潜在的应用.

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Acyl-PEGyl Exchange Gel Shift Assay for Quantitative Determination of Palmitoylation of Brain Membrane Proteins

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Author Spotlight: Evaluating Biophysical Assays for Characterizing PROTACS Ternary Complexes

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相关概念视频

Lipids as Anchors01:32

Lipids as Anchors

In the plasma membrane, the lipids forming the bilayer can also act as an anchor to tether proteins to the membrane. The three main types of lipid anchors found in eukaryotes are – prenyl groups, fatty acyl groups, and glycosylphosphatidylinositol or GPI groups. Prenyl and fatty acyl groups act as anchors on the cytosolic surface of the membrane, whereas GPI anchors proteins on the extracellular side.
The carboxy-terminal of most of the prenylated proteins, such as Ras proteins, contains the...