在乳腺癌中使用基线MRI和超声波进行新辅助疗法后预测部残留疾病
Caroline Malhaire1,2, Ozgun Umay3, Vincent Cockenpot4
1Institut Curie, Department of Medical Imaging, PSL Research University, 26 rue d'Ulm, 75005, Paris, France. caroline.malhaire@curie.fr.
European radiology
|February 7, 2025
概括
在结节阳性乳腺癌 (BC) 中,在新辅助疗法 (NAT) 后预测残留关节疾病是可以使用基线成像的. 关键预测因素包括瘤位置,皮质厚度和MRI上的T2信号强度.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 医疗成像医学成像
背景情况:
- 新辅助疗法 (NAT) 是节点阳性乳腺癌 (BC) 的标准治疗方法.
- 在NAT后准确预测残留关疾病 (ARD) 对治疗规划和患者管理至关重要.
- 基线成像特征可能有助于识别患有持续结节疾病风险较高的患者.
研究的目的:
- 开发和验证一个预测模型,用于关节残留疾病的关节阳性乳腺癌妇女治疗NAT.
- 评估基线乳腺BI-RADSMRI特征和腹超声波在预测ARD中的实用性.
- 为了确定NAT后残留关疾病的关键成像预测因子.
主要方法:
- 对141名患有结节阳性BC的妇女进行了回顾性分析,这些妇女接受了NAT.
- 使用BI-RADS词汇和T2特征对治疗前部超声波和乳房MRI进行评估.
- 开发一个多变量逻辑回归模型,在分割数据集 (7:3比) 上进行训练和测试.
主要成果:
- 41%的患者在NAT后出现了ARD.
- 独立预测ARD的预测因素包括光线亚型,前瘤位置和皮质厚度≥7mm.
- 内T2高信号强度被发现具有保护性 (OR,0.16;p=0.006).
- 预测模型的AUC值为0.860 (训练) 和0.843 (测试).
结论:
- 前部瘤位置,皮层厚度>7毫米,没有内T2过强度预测NAT后ARD.
- 开发的预测模型,结合BC亚型,Ki-67,瘤位置和成像特征,可以指导NAT后的股管理.
- 基线成像特征对于识别NAT后患有持续结节疾病风险的患者是有价值的.
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