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膜口表面积作为MRONJ发育的局部风险因素在多药性瘤患者
Rellyca Sola Gracea1,2,3, Isti Rahayu Suryani4,5, Rocharles Cavalcante Fontenele4
1OMFS-IMPATH Research Group, Department of Imaging & Pathology, Faculty of Medicine, KU Leuven & Department of Oral and Maxillofacial Surgery, University Hospitals Leuven, Leuven, Belgium. lola.gracea@kuleuven.be.
与药物相关的骨缩 (MRONJ) 风险随着口表面积的增加和多药房患者更多的下根的提取而增加. 对这些患者的谨慎管理,特别是在下抽取期间,对于减少MRONJ发病率至关重要.
科学领域:
- 口腔和牙面部外科手术
- 牙科植入物学 牙科植入物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 与药物相关的骨 (MRONJ) 是特定药物治疗患者的牙提取后的一种严重并发症.
- 涉及多种药物的多药性在需要广泛的牙科手术的患者中很常见.
- 了解MRONJ的风险因素对于患者的管理和预防至关重要.
研究的目的:
- 为了研究膜口表面积,提取的牙根数量和MRONJ的发展之间的关系.
- 为了评估这些因素,特别是在多药房患者进行多次牙拔除.
主要方法:
- 一项回顾性研究分析了40名患者 (20名MRONJ患者,20名对照患者),其中包括209名牙拔除.
- 形束计算断层扫描 (CBCT) 用于测量气泡口表面积.
- 统计分析探讨了在多药店患者中提取的根,口区域和MRONJ发育之间的相关性.
主要成果:
- 在多药房患者中,牙发生在40%的拔牙患者中,在下发生率更高 (44%).
- 在MRONJ发育与下牙根的数量 (r=+0.861) 和口牙总暴露表面积 (r=+0.757) 之间发现了强烈的正相关性.
- 在上下中没有观察到显著的相关性.
结论:
- 膜膜口表面积和拔牙根数量是多种拔牙患者中MRONJ发展的显著积极预测指标.
- 识别高风险患者和实施预防策略对于减少MRONJ发病率至关重要.
- 密切监测和谨慎管理对于多药房患者至关重要,特别是那些接受下牙取牙的人.
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