在药物废水中出现MDR Enterobacter hormaechei RSM5及其对β-lactam抗生素除去废水的影响
Swati Srivastava1, Virendra Singh Rana2, Rajni Singh3
1Amity Institute of Microbial Technology, Amity University, Uttar Pradesh, Sector-125, Noida, 201301, India.
Current microbiology
|February 7, 2025
概括
制药污水含有抗生素耐药的细菌,其中Enterobacter hormaechei RSM5表现出高抗素耐药性并降解了抗生素. 这突出了对公众健康的重大威胁和生物修复的潜力.
科学领域:
- 环境微生物学环境微生物学
- 抗微生物耐药性研究的研究.
- 生物技术是生物技术.
背景情况:
- 抗生素耐药性是一个主要的全球健康威胁,由制药废物加剧.
- 贝塔乳酸抗生素 (BLA) 广泛使用,但对耐药性有显著的贡献.
- 工业废水处理将高度的抗生素引入环境.
研究的目的:
- 为了研究药品废水中的抗生素耐药细菌菌株.
- 描述一种具有高抗素耐药性的多抗药性分离物.
- 探索耐药细菌对抗生素降解的潜力.
主要方法:
- 从制药废水中分离和选细菌菌株.
- 确定安培的最小抑制度 (MICs).
- 鉴定细菌分离物和评估抗生素耐药性概况.
- 高性能液体色谱 (HPLC) 用于抗生素降解分析.
主要成果:
- 在废水中发现了50多种抗生素耐药细菌菌株.
- 肠杆菌hormaechei RSM5表现出高抗素耐药性 (MIC>15,000微克/毫升) 并产生β-乳酸酶.
- 这种多药耐药菌株在24小时内使安皮西林降解了100%.
- 通过HPLC证实了安皮西林被分离物降解.
结论:
- 制药废水是多药耐药细菌的储存库.
- 肠杆菌 hormaechei RSM5 显示出显著的安皮西林耐药性和降解能力.
- 这一发现表明,抗生素污染地区的生物修复有可能发生.
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