关于在瘤学中进行预测,预后和连续生物标志物测试的成本效益分析的建议
Astrid Kramer1, Lucas F van Schaik2,3, Daan van den Broek4
1Department of Epidemiology and Data Science, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
PharmacoEconomics
|February 7, 2025
概括
对生物标志物的成本效益分析 (CEA) 面临挑战. 本综述探讨了不同生物标志物应用如何解决这些问题,并为未来的评估提供了建议.
科学领域:
- 生物医学和卫生服务研究研究研究
- 卫生经济学 卫生经济学
- 翻译医学是一种翻译医学.
背景情况:
- 生物标志物的成本效益分析 (CEA) 提出了独特的挑战,包括间接的健康结果影响和数据限制.
- 缺乏实践指导,用于进行可靠的生物标志物CEA.
研究的目的:
- 检查CEA对预测,预后和串行生物标志物应用如何解决现有挑战.
- 制定基于证据的建议,以改善未来的生物标志物CEA实践.
主要方法:
- 在三个生物标志物应用中进行了范围审查:预测性,预后性和串行测试.
- 关于模型假设,不确定性和结果的数据来自43个包含的CEA.
- 一个深入的分析侧重于模型假设在审查的研究中的影响.
主要成果:
- 分析了43个CEA,主要关注预测生物标志物 (31项研究).
- 在报告测试性能及其灵敏度分析方式方面发现了差异.
- 很少有研究探讨了对测试结果或跨生物标志物子组治疗效果变化的次优坚持的影响.
结论:
- 在不同应用中确定了解决生物标志物CEA挑战的各种策略.
- 制定了关于假设,不确定性处理和结果报告的建议,以推进生物标志物成本效益评估中的建模实践.
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