uN2CpolyG介导的p65核封存抑制了神经元内核包容性疾病中的NF-κB-NLRP3通路

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Updated: May 29, 2025

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Published on: January 12, 2020

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Yu Shen1, Kaiyan Jiang1, Dandan Tan1,2,3

  • 1Department of Neurology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Yong Wai Zheng Street 17#, Nanchang, 330006, China.

Cell communication and signaling : CCS
|February 7, 2025
PubMed
概括

神经内核包容性疾病 (NIID) 涉及一种蛋白质 (uN2CpolyG) 隔离一个关键的炎症调节器 (p65),抑制NF-κB-NLRP3通路并损害自. 这一发现为NIID和相关的蛋白质聚合障碍提供了一个新的治疗点.

关键词:
自自是一种自的过程.CGG重复扩张,重复扩张.通过NF-κB路径.在NLRP3炎症酶体中,NLRP3炎症神经元内核包容性疾病是神经元内核包容性疾病.单细胞测序是一种单细胞测序.

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