帕金森病中姿势控制的神经成像和认知相关物:系统性审查
Patrick Tait1, Lisa Graham1,2, Rodrigo Vitorio1,3
1Department of Sport, Exercise and Rehabilitation, Northumbria University, Newcastle Upon Tyne, UK.
Journal of neuroengineering and rehabilitation
|February 7, 2025
概括
帕金森病 (PD) 导致与认知问题相关的姿势不稳定. 皮质大脑活动似乎补偿皮质下损伤,影响患者的平衡和跌倒风险.
科学领域:
- 神经科学是一个神经科学.
- 运动障碍 运动障碍
- 认知神经学 认知神经学
背景情况:
- 帕金森病 (PD) 的特点是运动和非运动症状 (NMS),包括认知功能障碍.
- 姿势不稳定和跌倒是PD的重大并发症,影响患者的生活质量.
- 了解PD体位控制缺陷的神经支对于开发有效干预措施至关重要.
研究的目的:
- 对帕金森病中姿势控制的神经机制的当前研究进行审查和综合.
- 探索认知功能障碍,非运动症状和PD中的姿势不稳定之间的关系.
- 确定该领域新兴的研究技术和发现.
主要方法:
- 对Scopus,PubMed和ProQuest数据库进行系统的文献搜索.
- 包括使用行为评估,功能神经成像和静止状态神经相关的研究.
- 分析了79项确定的研究,详细介绍了脑成像技术,队列和姿势控制措施.
主要成果:
- 有证据表明,皮质区域参与维持PD的姿势控制.
- 皮层参与似乎是对潜在的皮层下神经退行症的补偿机制.
- 审查的研究强调了PD中运动,认知和姿势缺陷之间的复杂相互作用.
结论:
- 皮层参与在补偿帕金森病中皮层下损伤方面发挥着至关重要的作用,影响着姿势稳定性.
- 建议对结果测量和数据分析进行标准化,以提高未来研究的可靠性和有效性.
- 进一步研究PD中姿势控制的神经相关物是有必要的,以改善患者管理和降低跌倒风险.
相关概念视频
Parkinson's Disease: Overview
436
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
436
Neural Regulation
39.1K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.1K
Parkinson's Disease: Treatment
189
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
189


