调节正在发育的肠道微生物群,使用2'-糖糖和汇集的人类牛奶寡糖化合物
Simone Renwick1, Annalee Furst1, Mikael Knip2,3,4
1Family Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence (MOMI CORE), the Human Milk Institute (HMI), Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA, USA.
Microbiome
|February 7, 2025
概括
汇集的人类牛奶寡糖化物 (HMO) 显著改变儿童的肠道微生物群组成和活性. 单个HMO如2-fucosyllactose (2'FL) 的影响最小,这表明复杂的混合物是调节肠道微生物群的关键.
科学领域:
- 微生物学 微生物学
- 营养科学 营养科学
- 胃肠病学 胃肠病学
背景情况:
- 合成人乳寡糖 (HMO) 越来越多地用于婴儿配方奶粉.
- 它们对断奶后发育中的肠道微生物群的确切影响尚不清楚.
- 这项研究调查了特定HMO对幼儿微生物群落的影响.
研究的目的:
- 评估聚合的HMO (pHMOs) 和2-fucosyllactose (2'FL) 对培养肠道微生物群的组成和活性的影响.
- 了解个体细菌物种对HMO的反应.
- 为了确定微生物群产生的潜在的与健康相关的代谢物.
主要方法:
- 从七名健康儿童身上培养出便衍生的微生物群落.
- 将这些社区暴露在0.5g/L的2'FL和4.0g/L的pHMO中.
- 分析微生物群落的转移和代谢产量,包括培养和测试330种细菌分离物.
主要成果:
- pHMOs显著改变了微生物组成,增加了细菌类的丰富性,并产生了与健康相关的代谢物.
- 单独2'FL并没有引起微生物群落的实质性变化.
- 超过100种非Bifidobacterium物种在pHMOs下表现出增强的生长,揭示了HMO代谢的显著物种内变异.
结论:
- 聚合的HMO通过调节肠道微生物群,显示出增强健康的特性.
- 需要进一步研究婴儿配方中单个HMO结构对向微生物群调节的有效性.
- 这些发现有助于理解HMO在婴儿肠道健康中的作用.
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