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内脏脂肪代谢得分和中风之间的关联:通过降低功能调解
Yue Cao1, Weixing Wen1, Hao Zhang1
1Department of Cardiology, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), NO. 1 Jiazi Road, Lunjiao, Shunde District, Foshan City, Guangdong, 528308, China.
通过内脏脂肪代谢得分 (METS-VF) 测量较高的内脏脂肪,显著增加中风风险,特别是当METS-VF超过7.00时. 功能下降部分调解了这种关联.
科学领域:
- 心血管疾病流行病学
- 代谢健康和肥胖问题
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 卒中是全球死亡和残疾的主要原因之一.
- 由内脏脂肪代谢得分 (METS-VF) 评估的内脏肥胖与代谢疾病有关.
- METS-VF与中风风险之间的关系尚未得到充分证实.
研究的目的:
- 调查METS-VF与中风风险之间的关联.
- 探索功能在这种关系中的潜在调解作用.
主要方法:
- 从1999-2020年国家健康和营养检查调查 (NHANES) 中对19109名参与者的分析.
- 权重后勤回归和限制立方线来评估METS-VF和中风风险.
- 使用估计的膜过率 (eGFR) 和子组/敏感性分析 (PSM,多重归算) 的调解分析.
主要成果:
- 升高的METS-VF显示与中风风险增加有显著关联 (OR=2.78).
- 观察到一种非线性关系,风险在7.00的METS-VF以上急剧升级.
- 降低的eGFR调解了METS-VF中风联系的26.72%;这种联系在男性中更强烈.
结论:
- METS-VF是中风风险的独立预测指标.
- METS-VF和中风之间的关联是非线性的.
- 功能下降在内脏脂肪和中风之间的关系中起着调解作用.
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