母亲和自我发展的Streptococcus suis特异性抗体的动态
Sandra Vreman1, Rutger Jansen2, Mikael Bastian3
1Wageningen Bioveterinary Research, Wageningen University & Research, P.O. Box 65, Lelystad, 8200 AB, The Netherlands. sandra.vreman@wur.nl.
Porcine health management
|February 7, 2025
概括
小猪对Streptococcus suis感染的敏感性与母亲抗体的下降和低出生体重有关. 早期大奶粉摄入量和体重增加对于强大的抗体水平和小猪免疫力至关重要.
科学领域:
- 兽医免疫学 兽医免疫学
- 猪的传染病 猪的传染病
- 动物健康 动物健康
背景情况:
- 瑞士白杆菌 (S. suis) 感染对小猪造成了重大疾病负担,影响了福利和增加了抗生素的使用.
- 由于母源抗体 (MDA) 降低和获得免疫力不足,断奶猪的"免疫缺口"可能会增加对S. suis.的敏感性.
- 两项研究研究了抗体水平和小猪参数在S. suis易感性中的作用.
研究的目的:
- 评估母猪抗体,出生参数和一天大的小猪中S. suis特异性抗体水平之间的关联.
- 评估从出生到10周大的小猪体中S. suis特定和总抗体的动力学.
- 为了确定S. suis桃体载体身份在母猪和小猪在断奶前和后.
主要方法:
- 研究I:在四个农场评估母猪胆乳/血清抗体,出生参数和小猪抗体 (血清型2和9).
- 研究II:在一家农场从出生到10周监测小猪的抗体水平 (S. suis-specific和总量).
- 在母猪和小猪中分析了S. suis血型2和9载体状况的桃体拭子.
主要成果:
- 在农场之间和农场内观察到的S. suis抗体水平的高变化.
- 针对S. suis的MDA在24小时后下降,在18/19天左右达到最低水平,随后可能由于获得的免疫力而增加.
- 大奶粉摄入量,出生体重和24小时体重增加与出生和晚年S. suis抗体水平有正相关.
结论:
- 对S. suis的血清抗体水平在分娩后下降,在断奶前达到最低.
- 低出生体重和晚出生的小猪表现出降低的MDA和获得的抗体,增加了S. suis的易感性.
- 大奶粉摄入量和24小时体重增加显著影响早期的S. suis特异性抗体水平.
关键词:
这是一种Streptococcus suis.抗体是一种抗体.大奶粉是什么? 大奶粉是什么? 大奶粉是什么?实地研究 实地研究免疫缺口是一个缺口.母亲衍生抗体 (MDA) 是指来自母亲的抗体.一个小小的小猪.种植 播种 种植 播种更多相关视频
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