相关实验视频
Updated: Jun 27, 2026
08:31
Porous Silicon Microparticles for Delivery of siRNA Therapeutics
Published on: January 15, 2015
10.9K
可降解的半孔性有机纳米颗粒涂上素-Cu2+复合体,具有双刺激-反应,可有效地输送
Yibing Yan1, Fangxiang Song2, Songye Li1
1School of Pharmacy, Guizhou University, Guiyang 550025, China; Guizhou Engineering Laboratory for Synthetic Drugs, Guizhou University, Guiyang 550025, China.
International journal of biological macromolecules
|February 8, 2025
概括
这项研究开发了一种使用功能化纳米粒子和酸盐的新型双响应农药输送系统. 该系统提高了农药的有效性和粘附性,同时确保了大米种植的生物安全性.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
- 农业化学 农业化学
背景情况:
- 准确的农药应用对于效率和环境安全至关重要.
- 开发先进的输送系统可以提高农药的性能并降低风险.
- 基于纳米颗粒的载体为控制和向的杀虫剂释放提供了潜力.
研究的目的:
- 构建和评估使用氨基功能化可降解的半孔性有机纳米颗粒 (DMON-N) 和酸盐 (CS) 的pH/redox双响应的酸盐输送系统.
- 评估开发的用于控制大米病的输送系统的物理化学性质,受控释放和农业应用潜力.
主要方法:
- 制造一个双响应的输送系统 (CCPD) 通过交叉链接 Cu2+ - 基托复合物与载有 prochloraz (PRO) 的 DMON-N.
- CCPD系统的物理化学特征.
- 在不同的pH和氧化还原条件下评估PRO释放动力学.
- 评估大米叶的湿透性,粘附性和抗雨洗性.
- 与商业配方对抗米病原体的抗菌疗效的比较.
- 使用斑马鱼和人类支气管上皮细胞进行生物安全评估.
主要成果:
- CCPD系统表现出高的PRO负载能力 (29.09%) 和持续释放长达144小时,由酸度和谷氨触发.
- CCPD表现出极好的湿透性 (接触角度:63.52°),粘附性 (23.83 mg/cm2) 和抗冲洗性.
- 该系统的抗微生物疗效优于prochloraz技术和乳液配方的抗微生物疗效.
- 生物安全评估表明对斑马鱼,人类细胞的毒性最小,对大米没有负面影响.
结论:
- 开发的Cu-CS@PRO-DMON (CCPD) 系统是一个有效和安全的双响应的输送工具,用于prochloraz.
- 通过提高粘附性,控制释放和卓越的疗效,CCPD提高了农药的性能.
- 这种基于纳米技术的方法为农业中可持续和高效的害虫管理带来了希望.
相关概念视频
01:22Modified-Release Drug Delivery Systems: Rate-Programmed I
Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
01:30Modified-Release Drug Delivery Systems: Stimuli-Activated
Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
01:24Site-Targeted Drug Delivery Systems: Polymeric Carriers
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
01:11Oral Drug Delivery Systems: Delayed-Release Systems
Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...