在SARS-CoV-2感染后,婴儿进行肺功能测试
Avigdor Hevroni1, Talya Benenson-Weinberg2, Laurice S Boursheh2
1Department of Pediatrics and the Pediatric Pulmonology and CF Unit, Hadassah-Hebrew University Medical Center, Jerusalem, Israel; Department of Paediatrics, Assuta Medical Center, Ashdod, Israel.
与对照组相比,有SARS-CoV-2感染史的婴儿没有显著的长期肺功能差异. 这项关于婴儿肺功能测试 (iPFT) 的研究表明,该病毒没有独特的持久影响.
科学领域:
- 儿科肺病学 儿科肺病学
- 传染性疾病 传染性疾病
- 呼吸系统医学 呼吸系统医学
背景情况:
- 长期影响的SARS-CoV-2感染,特别是在婴儿,并没有很好地理解.
- 在SARS-CoV-2感染后评估婴儿的肺功能对于评估潜在的持久呼吸道影响至关重要.
研究的目的:
- 在有记录的SARS-CoV-2感染数月后评估婴儿肺功能测试 (iPFT).
- 为了比较对照组与SARS-CoV-2感染后持续呼吸道投诉的婴儿的iPFT结果.
主要方法:
- 采用了观察性病例控制研究设计.
- 婴儿肺功能测试 (iPFT) 对16名有SARS-CoV-2感染史的婴儿和475名对照进行了比较.
- 统计分析包括曼·惠特尼大学和费舍尔的精确测试,不包括患有慢性疾病或极度早产的婴儿.
主要成果:
- 在SARS-CoV-2组和对照组之间,肺体积,服从性或耐药性方面没有发现显著差异.
- 呼吸空气流量限制存在于两组中,在SARS-CoV-2组中发现的低肺体积流量略有改善.
- 在两组之间,对iPFT的生理变化和支气管扩展剂反应是相似的.
结论:
- 这项研究介绍了SARS-CoV-2感染后婴儿的最初全面的iPFT数据.
- 研究结果表明,SARS-CoV-2感染似乎不会在患有慢性呼吸道症状的婴儿中引起独特的长期肺功能缺陷.
- 建议对更大的队列进行进一步研究,特别是那些患有严重SARS-CoV-2感染的人,以证实这些观察结果.
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