进化生物学和医学中的好病原体神话的兴衰
Fabio Zampieri1, Fabio Michieletto2, Alberto Zanatta1
1University of Padua, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, Padua, Italy.
概括
"好病原体的神话"表明病毒进化后变得不那么有害. 然而,毒性传播权衡理论表明,中间毒性最大化了病原体的传播,影响了传染病的动态.
科学领域:
- 进化生物学 进化生物学
- 传染病流行病学 传染病流行病学
背景情况:
- 病原体进化的概念一直在争论,特别是在COVID-19大流行后.
- "好病原体的神话"基于史密斯的"毒性下降定律",假定病原体进化以减少对共存的危害.
- 疫苗和抗生素的过去成功创造了虚假的安全感,受到艾滋病等流行病的挑战.
研究的目的:
- 审查病毒性进化的历史概念.
- 根据当前的理解,批判性地检查"好病原体神话".
- 突出病毒性传播权衡理论的意义及其对进化医学的影响.
主要方法:
- 关于毒性进化的科学思想的历史审查.
- 对"好病原体神话"概念的分析.
- 解释"病毒传播权衡理论"及其数学模型.
主要成果:
- "良好的病原体神话"是对复杂的进化动态的过度简化.
- 毒性传播权衡理论提供了一个更准确的模型,表明中间毒性可以最大限度地提高病原性.
- 这一理论转变超越了二元适应/不适应逻辑.
结论:
- 进化医学为了解,预防和治疗传染病提供了一个至关重要的框架.
- 权衡理论对于理解流行病动态至关重要.
- 对公共卫生战略来说,重新思考毒性演变是必不可少的.
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