登革热病毒感染后的运动障碍:一个范围的审查
Elena Cecilia Rosca1,2, Divyani Garg3, Santiago Perez-Lloret4,5,6
1Department of Neurology, Victor Babes University of Medicine and Pharmacy Timisoara, Timișoara, Romania.
概括
登革热病毒 (DENV) 感染可以导致各种运动障碍,最常见的是小脑动. 需要进一步的研究来了解DENV.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 神经免疫学 神经免疫学
背景情况:
- 运动障碍是登革热病毒 (DENV) 感染的新出现的神经并发症.
- 了解这些疾病的临床谱和结果至关重要.
研究的目的:
- 综合DENV诱导的运动障碍的临床和准临床特征,治疗反应和结果.
- 审查可用的文献,并识别知识中的模式和差距.
主要方法:
- 在2023年9月之前对PubMed,Embase,Scopus和LILACS数据库进行系统审查.
- 包括73个报告的DENV诱导的运动障碍病例.
主要成果:
- 最常见的是小脑缩症,其次是帕金森症和克隆-肌克隆-缩症综合征.
- 运动障碍通常发生在DENV感染后的14天内,通常伴有认知和精神症状.
- 神经成像通常显示基底和脑干异常;治疗包括皮质类固醇和IVIG.
结论:
- DENV可以引发各种神经复杂症,包括免疫媒介运动障碍.
- 进一步的研究对于阐明机制,优化治疗和确定因果关系至关重要.
- 需要更严格的方法来确认DENV感染和运动障碍之间的联系.
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