莱诺克斯-加斯托综合征的神经刺激:来自CORE-VNS研究的24个月数据和经验
Paul Lyons1, James Wheless2, Ryan Verner3
1Virginia Comprehensive Epilepsy Program, Winchester, Virginia, USA.
Epilepsia
|February 8, 2025
概括
辅助迷走神经刺激 (VNS) 有效地减少了儿童和成年人患有伦诺克斯-加斯托综合征 (LGS) 的发作频率. 这种疗法证明了持续的疗效,并且耐受性很好,为这种具有挑战性的提供了有前途的治疗选择.
科学领域:
- 发病学 (Epileptology) 是一个专业的学科.
- 神经学 神经学
- 神经刺激是一种神经刺激.
背景情况:
- 伦诺克斯-加斯托综合征 (LGS) 的耐药性带来了重大的长期挑战.
- 传统的治疗方法往往不足以控制与LGS相关的发作.
- 神经刺激 (VNS) 正在作为耐性的辅助疗法进行研究.
研究的目的:
- 在患有伦诺克斯-加斯托综合征 (LGS) 的患者中评估辅助迷走神经刺激 (VNS) 的疗效和耐受性.
- 评估用VNS治疗的LGS患者的发作频率减少和患者报告的结果.
- 介绍24个月后的CORE-VNS研究中的中间分析数据.
主要方法:
- 展望性,多中心,多国观察性研究 (CORE-VNS) 涉及60名LGS参与者.
- 参与者接受了最初的迷走神经刺激 (VNS) 植入物.
- 发作频率和患者报告的结果在基线和植入后最多24个月内被收集.
主要成果:
- 在24个月后,LGS反应率 (≥50%的发作减少) 为焦点发作66.7%,一般发作47.4%.
- 20%的参与者实现了总发作频率降低≥80%.
- VNS耐受性良好,有15%的人报告治疗出现的不良事件,主要是轻微和短暂的.
结论:
- 辅助VNS治疗显著降低了主要是儿科LGS患者的发作频率,包括那些严重认知障碍患者.
- 持续的反应和良好的安全概况支持VNS作为伦诺克斯-加斯托综合征的有希望的治疗选择.
- 在LGS中,VNS提供了一种有价值的辅助治疗方法,用于管理耐药性发作,改善患者的治疗结果.
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