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Updated: May 29, 2025

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

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针对瘤细胞特异性幸存者基因沉默和抗瘤治疗的NQO1-可激活的循环反感性寡核酸

Xiaoran Zhao1, Jianfei Xu1, Xingxing Liang1

  • 1State Key Laboratory of Natural and Biomimetic Drugs, Chemical Biology Center and School of Pharmaceutical Sciences, Peking University, No. 38, Xueyuan Rd, Beijing 100191, China.

Journal of medicinal chemistry
|February 8, 2025
PubMed
概括

在瘤细胞中,一种新型的循环反感性寡核酸 (cASO) 被NAD(P) H:酸氧降解酶-1 (NQO1) 激活. 这种NQO1响应系统实现了瘤特异性基因沉默,并显示出显著的抗瘤效应.

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Evaluation of Exon Inclusion Induced by Splice Switching Antisense Oligonucleotides in SMA Patient Fibroblasts

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