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空间蛋白质组学识别了一条依赖CRTC的病毒信号通路,该通路刺激了11-interleukin的产生

Benjamin J Ravenhill¹, Marisa Oliveira¹, George Wood²

¹Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK; Department of Medicine, University of Cambridge, Cambridge, UK.

|February 8, 2025

概括

病毒感染触发细胞传感器,导致蛋白质运动. cAMP-响应元素结合蛋白 (CREB) 调节的转录协活性剂2和3 (CRTC2/3) 移动到核中,促进对抗病毒防御至关重要的互白素-11 (IL-11) 生产.

科学领域:

免疫学免疫学免疫学
细胞生物学细胞生物学
病毒学病毒学

背景情况:

细胞对病毒的识别对于免疫反应至关重要.
病毒传感器通过触发信号通路来启动宿主防御.
许多病毒传感器在激活后在细胞内重新安置,以诱导抗病毒基因表达.

研究的目的:

通过分析蛋白质重新定位,在全球范围内识别与病毒感染有关的信号因子.
研究cAMP-响应元素结合蛋白 (CREB) 调控的转录协活性剂2和3 (CRTC2/3) 在宿主对病毒感染的反应中的作用.

主要方法:

在病毒感染期间蛋白质重新定位的全球分析.
研究了多种病毒感染后在不同细胞类型中CRTC2/3的亚细胞转移.
确定了CRTC2/3转位对线粒体抗病毒信号蛋白 (MAVS),环氧酶蛋白和蛋白质激酶A的依赖.

主要成果:

在感染各种病毒后,CRTC2/3表现出早期的细胞质到核转位.
这种转位取决于MAVS,循环氧酶蛋白和蛋白质激酶A.
CRTC2/3 核转位导致纤维炎性细胞因子介质素-11 (IL-11) 的转录.

结论:

核转位CRTC2/3是对病毒感染宿主反应的重要途径.
通过CRTC2/3诱导IL-11可能在与纤维化相关的病毒感染中具有临床意义,例如SARS-CoV-2.
确定了一种涉及CRTC2/3和IL-11生产的新型宿主防御机制.

关键词:

CP: 细胞生物学细胞生物学 CP: 微生物学微生物学在CRTC中,CRTC可以使用CRTC.仙台病毒的病毒介质氨基-11 介质氨基-11 介质氨基-11 蛋白质组学蛋白质组学系统病毒学病毒学.病毒的信号传递.

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