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相关概念视频

B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

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The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
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相关实验视频

Updated: May 6, 2026

Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation
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Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation

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在人类B细胞发育过程中预测基于单细胞网络的基因活动格局的协议.

Xin Huang1, Xuetong Hou2, Yizhen Li3

  • 1Precision Research Center for Refractory Diseases, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China.

STAR protocols
|February 8, 2025
PubMed
概括
此摘要是机器生成的。

这项研究引入了一种新的协议,用于使用基因调节网络分析人类B细胞的发育. 它有助于澄清B细胞亚型及其在发育过程中的生物特征.

关键词:
生物信息学是一种生物信息学.免疫学 免疫学 免疫学一个单细胞单细胞.系统生物学 系统生物学

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A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
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A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

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In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
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In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

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相关实验视频

Last Updated: May 6, 2026

Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation
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Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation

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A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
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A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

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In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
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In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

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科学领域:

  • 免疫学 免疫学 免疫学
  • 计算生物学 计算生物学
  • 基因组学就是基因组学.

背景情况:

  • 人类B细胞分类由于异质性而面临挑战.
  • 区分B细胞亚种群是很困难的.

研究的目的:

  • 为人类B细胞发育阶段构建基因调节网络和基因活动景观的协议.
  • 阐明人类B细胞发育的生物特征.

主要方法:

  • 获得骨髓数据.
  • 单细胞下游分析.
  • 使用SJARACNe,NetBID2和scMINER算法进行基于网络的分析.

主要成果:

  • 该协议提供了一种用于构建人类B细胞发育的基因调控网络的方法.
  • 它使得基因活动景观的创造成为可能.
  • 阐明了发育阶段的生物特征.

结论:

  • 开发的协议为研究人类B细胞发育提供了一个强大的框架.
  • 它解决了B细胞分类和亚种群识别中的不一致问题.
  • 这种方法增强了对B细胞生物学的理解.