维生素C依赖的代际遗传增强的耐力表现后母亲的运动
Haiwang Shi1, Jie Li1, Fan Li1
1School of Physical Education and Sports Science, South China Normal University, Guangzhou, Guangdong, 510006, China.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|February 8, 2025
概括
母亲的运动通过增强耐力来提高孩子的身体健康,跨越了几代人. 这种效应由维生素C (VC) 运输和DNA甲基化介导,提供了新的健康策略.
科学领域:
- 运动生理学 运动生理学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 发育生物学是发展生物学.
背景情况:
- 年轻人体力活动的下降是一个重大的公共卫生问题.
- 了解增强后代身体健康的机制至关重要.
- 越来越多地认识到母亲的生活方式对后代健康的跨代影响.
研究的目的:
- 调查母亲运动对后代身体健康的影响.
- 阐明这些跨代收益背后的分子机制.
- 探索维生素C (VC) 和DNA甲基化在调解这些效应中的作用.
主要方法:
- 在动物模型中对运动和不运动母亲的后代进行比较研究.
- 分析肌肉纤维组成,线粒体生物发生和基因表达.
- 研究DNA甲基化模式,特别针对Slc23a2基因.
- 在怀孕期间补充维生素C (VC) 的干预.
- 在肌体细胞中评估TET2表达.
主要成果:
- 母亲的运动显著改善了后代的耐力,改变了肌肉纤维类型并促进了线粒体生物发生.
- 这些好处在F1和F2代人中观察到,并与Slc23a2基因脱甲基化有关.
- 维生素C (VC) 管理模仿了运动的益处,而遗传VC缺乏消除了它们.
- 维生素补充剂上调了TET2表达,影响了DNA甲基化和肌性细胞发育.
结论:
- 通过维生素C (VC) - TET2-SVCT2通路,孕产妇的运动通过后代的耐力获得了跨代的改善.
- 这一途径涉及调节线粒体功能和肌肉发育的表观遗传修饰.
- 针对这一途径提出了一种新的策略,以提高母亲和儿童的身体健康.
更多相关视频
08:04Measuring Mitochondrial Electron Transfer Complexes in Previously Frozen Cardiac Tissue from the Offspring of Sow: A Model to Assess Exercise-Induced Mitochondrial Bioenergetics Changes
Published on: August 16, 2021
2.5K
07:52Assessment of Murine Exercise Endurance Without the Use of a Shock Grid: An Alternative to Forced Exercise
Published on: August 14, 2014
19.1K
相关概念视频
02:59Animal Mitochondrial Genetics
7.4K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
7.4K
01:47Lung Capacity
49.2K
The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
49.2K
01:20Exercise and Cardiovascular Response
706
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
706
01:27Exercise and Muscle Performance
1.3K
Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
1.3K
01:29Non-nuclear Inheritance
21.4K
Most DNA resides in the nucleus of a cell. However, some organelles in the cell cytoplasm—such as chloroplasts and mitochondria—also have their own DNA. These organelles replicate their DNA independently of the nuclear DNA of the cell in which they reside. Non-nuclear inheritance describes the inheritance of genes from structures other than the nucleus.
21.4K
01:20Gene-Environment Interactions
244
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
244