基于K-Carrageenan-Tapioca粉的蔬菜囊:一种可持续的等替代品-化合物和表征研究
Rajagopal Kumaravelrajan1, Kishore Metha Arockiyasamy2, Suba Venkatesan3
1Department of Pharmaceutics, C.L. Baid Metha College of Pharmacy, TN DR M.G.R. Medical University, Chennai, Tamil Nadu, India. rkumaravelrajan@gmail.com.
International journal of pharmaceutical compounding
|February 8, 2025
概括
卡帕-卡拉基南和塔皮奥卡粉显示出其作为药品囊的植物性替代品的前景. 优化的配方表现出优异的物理性能,分解和药物释放,适合药物输送.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 食品化学 食品化学
背景情况:
- 传统的凝囊面临由于动物起源和潜在的宗教/饮食限制的限制.
- 在药物剂量形式中对植物性替代品的需求越来越大.
- 卡拉基南和粉衍生物因其凝和膜形成特性而受到探索.
研究的目的:
- 调查卡帕-卡拉基南和基化塔皮奥卡粉作为硬囊制造的新型辅助剂.
- 开发和优化用于药品囊应用的配方.
- 评估开发的囊的物理化学,分解和药物释放特性.
主要方法:
- 通过使用卡帕-卡拉基和基烯化塔皮奥卡粉,制备了9种不同的配方.
- 用旋转模具方法进行封装.
- 描述包括粘度,外观,干燥损失,SEM分析,水分含量,分解,药物释放和稳定性研究.
主要成果:
- 优化的配方 (F8) 显示了合适的粘度 (11035 cps) 和可接受的干燥损耗 (33.5%).
- 囊表现出一致的尺寸,适当的水分含量,并在15分钟内迅速分解.
- 优化的囊在60分钟内释放了99.23%的药物,并表现出良好的稳定性.
结论:
- 卡帕-卡拉基南和基化塔皮奥卡粉是制药囊配方中等的可行替代品.
- 优化的配方符合药物输送的关键制药要求.
- 这些植物性囊为制药行业提供了一个有前途的可持续选择.
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