大脑白质的结构连接性创伤和创伤相关的解离障碍和症状
Lora I Dimitrova1, Sima Chalavi2, Eline M Vissia3
1Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK; Department of Psychiatry, Amsterdam UMC, Location VUmc, VU University Amsterdam, Amsterdam, The Netherlands.
Psychiatry research
|February 8, 2025
概括
这项研究揭示了与PTSD和健康对照相比,分离性身份障碍 (DID) 的女性的白质差异明显. 这些发现突出了与严重创伤相关的结构性大脑变化.
科学领域:
- 神经成像是一种神经成像.
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
背景情况:
- 童年创伤在分离性身份障碍 (DID) 和创伤后应激障碍 (PTSD) 中显著影响大脑结构和功能.
- 虽然已经记录了灰质变化,但与创伤相关的疾病,特别是DID中白质变化的研究仍然不足.
- 这项研究调查了创伤相关疾病患者的白质完整性.
研究的目的:
- 检查被诊断患有分离性身份障碍 (DID) 和创伤后应激障碍 (PTSD) 的个体的白质变化.
- 为了比较DID,PTSD和健康对照 (HC) 组之间的白质完整性.
- 探索白质完整性与解离/创伤严重程度之间的关系.
主要方法:
- 扩散张力成像 (DTI) 用于评估65名女性参与者的白质完整性 (17 DID,16 PTSD,32 HC).
- 基于Voxel的分析 (VBA) 描述了白质完整性,网络病变映射识别了相关的灰质区域.
- 参与者完成了解离和创伤的自我报告措施.
主要成果:
- 与HC相比,DID参与者在特定大脑区域观察到减少的分数异质性 (FA),包括白体,中脑和小脑白质.
- 与PTSD受试者相比,DID受试者在右侧内部囊和部区域呈现出增加的FA.
- 受影响的白质区域的FA值与非个性化,精神形态,体形态解离和创伤的分数负相关.
结论:
- 扩散张力成像的发现表明,与PTSD和健康对照相比,DID患者的白质完整性显著不同.
- 这些结果提供了对异常白质结构完整性在DID的受伤女性中所起的作用的关键机械洞察力.
- 这项研究强调了研究白质对于理解DID的神经生物学基础的重要性.
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