调查不同对认知障碍的二分法定义对二级渐进性MS中功能连接性的影响
Anisha Doshi1, Nils Muhlert2, Gloria Castellazzi3
1NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, Faculty of Brain Sciences, University College London Queen Square Institute of Neurology, University College London, London, United Kingdom.
Multiple sclerosis and related disorders
|February 8, 2025
概括
在二次渐进性多发性硬化症 (SPMS) 中定义认知障碍会影响大脑网络分析. 标准化标准对于准确的评估和MS中有效的治疗开发至关重要.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 神经学 神经学
背景情况:
- 改变的大脑网络功能与多发性硬化症 (MS) 的认知障碍有关.
- 现有研究表明,对于这些变化缺乏共识,可能是由于MS阶段或认知障碍定义的不同.
研究的目的:
- 为了调查二级渐进性多发性硬化症 (SPMS) 的认知障碍和功能连接 (FC).
- 用两个常见的二分法标准来评估认知障碍的CF变化.
主要方法:
- 休息状态功能性MRI (rs-fMRI) 用于65名SPMS受试者.
- 独立组件分析评估了静止状态网络.
- 认知障碍被定义为z-score ≤-1.96SD或 ≤-1.5SD在≥2个领域.
主要成果:
- 认知障碍的患病率在 -1.5SD (47%) 与 -1.96SD (30%) 标准相比较高.
- -1.96SD标准显示,FC (腹部注意力,感觉运动网络) 降低的地区增加了2.8倍.
- -1.96SD标准还显示,在增加FC (前状,听觉网络) 的地区增加了1.5倍.
结论:
- 认知障碍的选择标准显著影响全球FC模式.
- 不同的标准可以掩盖关键网络变化,可能会影响治疗干预的有效性.
- 建立认知障碍的商定截止值对于MS的临床管理和监测至关重要.
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