化疗对乳腺癌患者注意力功能的影响:纵向前性队列研究的元分析
Sun Ok Jung1, Ara Cho2, Dong Won Yang3
1Department of Nursing, Suwon Science College, Gyeonggido, South Korea.
概括
化疗 (CTX) 显著损害了注意力功能,特别是在治疗后的一年内,与健康个体相比. 这种影响注意力的认知衰退,即使在考虑到研究变异后,即使与非化疗患者相比也很明显.
科学领域:
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
- 在瘤学瘤学.
背景情况:
- 化疗的认知效应,通常称为"化学大脑",是越来越令人担忧的.
- 了解对注意力的确切影响对于患者护理至关重要.
- 在PROSPERO注册:CRD42023481642.2. 这是一个很好的方法.
研究的目的:
- 用神经心理测试量化疗对注意力功能的影响.
- 为了确定化疗影响注意力的时间点.
主要方法:
- 进行了对18项研究 (16个独立数据集) 的元分析.
- 在5个数据库中进行文献搜索.
- 对化疗 (CTX) 与非化疗患者 (NCP) 和健康对照 (HC) 计算的对冲的g效应大小.
- 分析神经心理测试中所花费的时间和准确性.
主要成果:
- 化疗患者在治疗后1年内表现出明显低于健康对照者的注意力 (ES = 0.36,p=0.05;ES = -0.30,p<0.01).
- 在排除了影响性研究后,化疗患者在1年内也表现出比非化疗患者更低的注意力 (ES = -0.22,p=0.03).
- 效果大小在1年内达到顶峰,表明化疗对注意力的延迟影响.
结论:
- 化疗明显恶化了患者的注意力功能.
- 研究结果表明,对注意力的影响是延迟的,而不是急性.
- 由于混合结果和有影响的异常因素,需要进行进一步的精心设计的研究;临床医生应该了解这些影响和支持性护理选择.
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