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Updated: May 28, 2025

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鉴定和描述一种新的ergothioneine联的raloxifene的鉴定和特征

Abhijith Rao1, Sivaprasad Putluru1, Prasanth Eapen1

  • 1Pharmaceutical Candidate Optimization, Biocon Bristol Myers Squibb R&D Center, Syngene International Limited, Bengaluru, Karnataka, India.

Drug metabolism and disposition: the biological fate of chemicals
|February 8, 2025
PubMed
概括

埃尔戈氨酸 (ET) 结合了拉洛西芬 (RX) 反应性代谢物,类似于谷氨 (GSH). 这项研究确定了ET作为一种新的异生菌解毒途径,可能降低药物毒性.

关键词:
生物活化 生物活化结合方式 结合方式葡萄糖氨酸 (Glutathione) 是一种对于L-ergothioneine来说,这是一个很好的方法.拉洛西芬的使用方法

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Internal Receptors01:31

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Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
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Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
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