生命前三年的神经发育并不能预测10岁时的精神病体验:一项前性队列研究
María Hernández-Lorca1, Martin Køster Rimvall2, Jens Richardt Møllegaard Jepsen3
1Center for Neuropsychiatric Schizophrenia Research (CNSR), Mental Health Centre Glostrup, University of Copenhagen, Glostrup, Denmark; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Schizophrenia research
|February 8, 2025
概括
早期神经发育迟缓与10岁儿童的精神病体验 (PE) 没有联系. 这项研究表明,童年PE可能不是来自非典型的早期发育. 需要对持续性PE进行进一步的研究.
科学领域:
- 儿童和青少年精神病学 儿童和青少年精神病学
- 发展心理学 发展心理学
- 神经科学是一个神经科学.
背景情况:
- 以前的研究表明,早期发育迟缓与儿童时期的精神病经历 (PE) 之间存在联系.
- 这些发现暗示了潜在的神经发育途径有助于儿童PE.
- 这项研究研究了10岁早期神经发育和PE之间的预测关系.
研究的目的:
- 为了检查从出生到3岁的神经发育是否预测10岁时的精神病体验 (PE).
- 研究早期发育里程碑,语言学习,认知和以后的PE之间的关联.
- 确定早期神经发育轨迹是否与中儿童期PE的出现有关.
主要方法:
- 利用了来自COPSAC2010纵向队列 (n=700) 的数据.
- 收集了关于儿童里程碑,语言,认知和从婴儿期到3岁的一般发展的前性数据.
- 通过临床评估和后勤回归分析,在10岁时对PE进行了儿童评估.
主要成果:
- 总共有593名儿童在10岁时被评估,其中13%报告PE.
- 在早期神经发育 (出生到3岁) 和10岁时的PE之间没有发现显著的关联.
- 排除患有神经发育诊断的儿童并没有改变研究结果.
结论:
- 早期发育 (前3年) 的延迟与中儿童时期的PE无关.
- 这些发现不支持童年PE是由非典型的早期神经发育引起的假设.
- 需要进一步的研究来探索与持久性PE的关联.
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