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Updated: May 11, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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新型BACE1抑制剂的开发与氧胺衍生的N-阿米迪诺皮罗利丁基架

Kazuya Kobayashi1, Chinami Taniguchi1, Misaki Tanaka1

  • 1Laboratory of Medicinal Chemistry, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8412, Japan.

Bioorganic & medicinal chemistry
|February 8, 2025
PubMed
概括

研究人员为BACE1抑制剂开发了一种新的氧胺衍生的支架,从而产生像12f这样的高度活性化合物. 这种新的支架显示出开发未来阿尔茨海默病治疗方法的前景.

关键词:
阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.阿米迪诺基团是阿米迪诺基团的一个组成部分.在BACE1中获得BACE1学位.氧氨酸是一种氧氨酸.蛋白酶抑制剂是一种蛋白酶抑制剂.

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