主要经历的感知歧视在整个生命和生物衰老
Roma Dhingra1, Abby R Hillmann2, Rebecca G Reed2
1Department of Biology, Georgetown College of Arts and Sciences, Georgetown University, Washington, DC, USA.
Psychoneuroendocrinology
|February 8, 2025
概括
在一生中经历歧视会加速生物衰老,特别是炎症. 年轻成年和中年似乎是这些免疫影响的敏感时期.
科学领域:
- 社会流行病学 社会流行病学
- 生物衰老 生物衰老
- 免疫学 免疫学 免疫学
背景情况:
- 感知终身歧视与加速的生物衰老有关.
- 具体的生命阶段最容易受到歧视的生物影响仍然不清楚.
研究的目的:
- 调查不同生命阶段感知到的终身歧视与生物衰老标志物之间的关联.
- 为了确定敏感的发育时期的歧视的免疫效应.
主要方法:
- 利用了2986名健康和退休研究参与者的数据 (平均年龄68岁).
- 测量了整个生命和特定阶段 (童年,年轻成人,中年,晚年成人) 的感知终身歧视.
- 通过炎症标志物 (CRP,IL-6,sTNFR-1) 和使用血液样本的表观遗传年龄来评估生物衰老.
主要成果:
- 较高的总体感知终身歧视与CRP和IL-6水平升高相关.
- 年轻成人时期的歧视与较高的IL-6相关.
- 年轻成人和中年人的歧视独立地与45岁以上的成年人分别较高的IL-6和CRP有关.
- 没有发现与sTNFR-1或表观遗传年龄有重大关联.
结论:
- 感知到的终身歧视,无论是累积的还是在特定的成人生活阶段,都与晚年炎症的增加有关.
- 年轻的成年期和中年期代表了歧视可能产生最显著的免疫效应的关键时期.
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