相关实验视频

Updated: May 28, 2025

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Published on: March 15, 2024

华中药注射通过NRF2/HO-1信号通路诱导多发性骨髓瘤中的铁亡

Jing Yang¹, Fengnan Wang¹, Zhongxiao Hu²

¹Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210029, China; The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210029, China.

Journal of ethnopharmacology

|February 8, 2025

概括

华 (HCS) 通过NRF2/HO-1通路诱导铁亡,从而触发多发性骨髓瘤 (MM) 中的细胞死亡. 这种天然化合物为MM治疗提供了一个有前途的治疗策略.

科学领域:

在瘤学瘤学.
药理学药理学是指药理学的学科.
细胞生物学细胞生物学

背景情况:

多发性骨髓瘤 (MM) 是一种流行的血液性恶性瘤.
华松 (HCS),来自Bufo bufo gargarizans,表现出多目标的抗瘤作用.
在治疗MM中HCS的确切机制尚未完全理解.

研究的目的:

阐明HCS诱导多发性髓瘤细胞死亡的细胞和分子机制.
为了研究铁化在HCS介导的MM细胞死亡中的作用.

主要方法:

细胞活力通过CCK-8测定进行评估.
用于分析基因表达的转录组测序,qRT-PCR,西斑和免疫光学.
测量了铁灭标志物 (铁度,MDA,GSH,ROS,PGSK) 的测量.
在异种移植裸体小鼠模型上进行的体内研究.
使用传输电子显微镜可视化线粒体损伤.

主要成果:

HCS通过促进铁亡来诱导MM细胞死亡,其特征是铁,ROS,MDA和PGSK的增加,GSH的减少.
该NRF2 / HO-1通路由HCS调节,上调PRP和ZIP8.8.
铁灭抑制剂逆转了HCS诱导的影响,HCS在体内显示出有效性,与博尔特佐米布相当.

结论:

HCS通过NRF2/HO-1通路诱导多发性骨髓瘤细胞中的铁亡,从而控制疾病的进展.
这项研究为MM中HCS的临床应用提供了理论基础.
HCS代表了一个潜在的新型治疗途径,可能与化疗结合使用.

关键词:

在Cinobufagin中使用.铁化是铁化的一种.这就是HO-1的HO-1.华夏苏州华夏苏州是一个多发性骨髓瘤是一种多发性骨髓瘤.

更多相关视频

Ferritinophagy: Assessing the Selective Degradation of Iron by Autophagy in Human Fibroblasts

Ferritinophagy: Assessing the Selective Degradation of Iron by Autophagy in Human Fibroblasts

Published on: February 23, 2024

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos

Published on: December 13, 2018

相关概念视频

Necrosis

Necrosis

Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...