美国年轻成年人使用他类药物和心血管风险
Om A Kothari1, John Stone1, Alan Manivannan1
1Department of Medicine, Section of General Internal Medicine, Boston Medical Center, Boston, Massachusetts.
American journal of preventive medicine
|February 8, 2025
概括
在年轻成年人 (20-39岁) 中,用于初级预防的他类药物处方率很低,为0.43%. 大多数处方他类药物的患者不符合PREVENT风险评分标准,这表明目前在这个年龄组使用的证据有限.
科学领域:
- 心脏病学 心脏病学
- 预防医学 预防医学
- 公共卫生 公共卫生
背景情况:
- 动脉样性心血管疾病 (ASCVD) 始于成年早期.
- 对年轻成年人使用他类药物进行初级预防的指导是有限的.
- 了解这个人口群体当前的他类药物处方模式至关重要.
研究的目的:
- 检查年轻成年人 (20-39岁) 在初级预防中使用他类药物的率.
- 为了比较年轻成年人处方他类药物和非处方他类药物的特征.
- 评估接受他类药物的年轻成年人预防ASCVD风险评分.
主要方法:
- 对775,162名年龄在20-39岁之间的成年人进行了回顾性多中心队列研究.
- 包括至少有一次LDL-C测量的患者.
- 在LDL-C测试后1个月内分析了他类药物处方,并比较了PREVENT风险得分.
主要成果:
- 在0.43% (3,309/775,162) 的年轻成年人中,开始使用他类药物治疗.
- 处方他类药物的患者更有可能是老年人,男性,并且LDL-C,SBP,HbA1c和BMI都较高.
- 与未处方他类药物患者相比,处方他类药物的平均和较低风险患者的PREVENT风险得分与未处方他类药物患者相似或更高.
结论:
- 对于年轻成年人来说,用于初级预防的他类药物处方并不常见.
- 处方他类药物的年轻成年患者平均不符合PREVENT风险标准.
- 关于他类药物在这个年龄组中用于初级预防的成本效益的进一步研究是有必要的.
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