与晚期细胞癌免疫疗法组合相关的内分泌毒性:基于专家的实际管理建议
Carla Colombo1, Simone De Leo2, Ilaria Campisi3
1Endocrine Oncology Unit, Department of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.
Critical reviews in oncology/hematology
|February 8, 2025
概括
基于免疫的组合是转移性细胞癌的标准,但可能导致毒性. 本次审查侧重于管理内分泌不良事件,以确保治疗成功.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 内分泌学 在内分泌学.
背景情况:
- 基于免疫的组合 (免疫疗法或免疫疗法加氨酸激酶抑制剂) 是转移性细胞癌的标准一线治疗方法.
- 与治疗相关的毒性经常导致药物停用或剂量减少.
- 在这些组合中,内分泌毒性是常见的,需要谨慎管理.
研究的目的:
- 审查一线转移性细胞癌治疗中与治疗相关的内分泌病变的证据.
- 讨论用于诊断内分泌不良事件的监测策略.
- 为管理这些毒性提供实用工具.
主要方法:
- 对针对细胞癌的基于免疫的组合研究的文献综述.
- 分析有关内分泌毒性的证据.
- 讨论诊断和管理策略.
主要成果:
- 内分泌毒性很常见,但通常是可以控制的.
- 诊断可能很复杂,有时需要多学科的投入.
- 在组合疗法中识别特定的致病原体可能是具有挑战性的.
结论:
- 有效预防和管理内分泌毒性对于细胞癌的免疫基组治疗成功至关重要.
- 系统监测和多学科方法对于最佳的患者护理至关重要.
- 需要为临床医生管理这些不良事件提供实际指导.
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