由CO2依赖性Streptococcus pneumoniae血清型24F序列类型162引起的侵入性肺炎球菌病:一个病例报告
Takahiko Niwa1, Takehisa Matsumoto2, Misako Ohkusu3
1Clinical Laboratory Center, Gunma University Hospital, Maebashi, Japan.
概括
一个罕见的侵袭性肺炎球菌病 (IPD) 病例发生在一位老年男性身上,病因是依赖于二氧化碳的肺炎球菌. 这种血清型24F ST162菌株,此前在儿童中发现,突显了在成人IPD病例中需要保持警.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 基因组学就是基因组学.
背景情况:
- 侵入性肺炎球菌病 (IPD) 是一个重要的全球健康问题.
- 肺炎链球菌通常需要标准的大气条件才能生长.
- 碳依赖性S. pneumoniae菌株是一个新兴的问题,特别是在特定的血清型和序列类型中.
研究的目的:
- 报告一名老年患者首例因二氧化碳依赖性Streptococcus pneumoniae血清型24FST162.2.引起的IPD病例.
- 通过血清型定型和全基因组测序来表征该分离物.
- 强调这种病原体在成年人群中的潜力.
主要方法:
- 一个老年男性患者的病例报告,怀疑肺炎.
- 诊断程序包括胸部X射线,CT扫描,唾液培养,血液培养和尿液肺炎球菌抗原检测.
- 抗微生物敏感性测试和治疗调整.
- 单独的S. pneumoniae菌株的血清定型和全基因组测序.
- 基因分析以确定突变,特别是murF基因中的突变.
主要成果:
- 一种依赖CO2的Streptococcus pneumoniae血清型24F ST162被确定为老年男性患者IPD的致病原体.
- 这名患者接受了塞夫特里亚克松,后来接受了硫巴克坦/安皮西林治疗,但不幸的是,他因感染而死亡.
- 与参考菌株相比,全基因组测序揭示了murF基因的特定突变 (c.536C>T).
- 这代表了在老年人中首次被记录的IPD病例,该病例是由这种特殊菌株引起的.
结论:
- 在CO2依赖性肺炎链球菌血清型24FST162可以导致严重的侵袭性疾病在老年人.
- 临床警对于识别和管理由异常或新出现的S. pneumoniae菌株引起的IPD至关重要.
- 需要进一步研究CO2依赖性S. pneumoniae在成年人群中的流行病学和临床影响.
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