维生素D补充,慢性阻塞性肺病和喘恶化,以及肺功能下降
Diane R Gold1, Vincent J Carey2, Craig P Hersh2
1The Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, United States; The Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, United States; Harvard Medical School, Boston, MA, United States.
The Journal of nutrition
|February 8, 2025
概括
维生素D补充剂没有减少COPD或喘患者的恶化或改善肺功能. 这项研究发现,在没有维生素D缺乏的成年人中,对呼吸系统健康没有显著的益处.
科学领域:
- 呼吸系统药物 呼吸系统药物
- 营养科学 营养科学
- 临床试验中的临床试验.
背景情况:
- 慢性阻塞性肺病 (COPD) 和喘的急性恶化显著增加了全球疾病负担.
- 维生素D补充剂在减少这些恶化的有效性仍然不确定.
研究的目的:
- 评估维生素D补充剂与安慰剂对急性COPD和喘恶化的影响.
- 评估维生素D对肺功能的影响,特别是气流阻塞的减少.
主要方法:
- 肺维生素D和OmegaA-3 TriaL (VITAL) 研究招募了3600多名有呼吸道恶化风险的参与者.
- 参与者接受了维生素D3 (2000 IU/d) 或安慰剂,并通过问卷和螺旋计测试对子组进行了5年的随访.
主要成果:
- 补充维生素D与降低COPD或喘恶化的风险没有关联.
- 在维生素D和安慰剂组之间,在COPD恶化率上没有发现显著差异.
- 在2年的随访期间,补充剂并没有减缓1秒内强迫呼气体积 (FEV1) 的下降.
结论:
- 与安慰剂相比,维生素D补充剂在没有维生素D缺乏症的成年人中没有降低COPD恶化率或增强肺功能.
- 这些发现表明,维生素D补充剂对预防呼吸道恶化或维持肺功能在这个人群中没有好处.
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