酸盐食补充剂提高了世卫组织第三组肺高血压患者的运动能力:双盲,安慰剂控制,随机交叉研究 (EDEN-OX2)
Abdullah S Alsulayyim1,2, Ali M Alasmari1,3, Laura C Price1,4
1National Heart and Lung Institute, Imperial College London, London, UK.
Thorax
|February 8, 2025
概括
使用甜菜汁的食酸盐补充剂显著改善了肺高血压患者的运动耐力和血管功能. 这一发现表明,对治疗这种肺部疾病有潜在的益处.
科学领域:
- 心血管研究研究心血管研究
- 肺部医学 肺部医学
- 营养科学 营养科学
背景情况:
- 酸盐食补充剂可提高慢性阻塞性肺病中氧气利用率和运动能力.
- 肺高血压 (PH) 的特点是肺动脉血压升高,导致运动能力降低.
- 3组PH的个体经常经历运动诱导的脱度,突出了改善表现的干预措施的需要.
研究的目的:
- 研究饮食中酸盐补充剂对3组肺高血压的成年人运动能力和血管功能的影响.
- 评估富含酸盐的甜菜汁对耐力穿行走时间和内皮功能的影响.
- 为了评估酸盐补充剂后平均动脉血压的变化.
主要方法:
- 进行了一项双盲,安慰剂控制的交叉研究.
- 19名患有第三组肺高血压的成年人在运动期间脱.
- 参与者在交叉设计中接受了140毫升富含酸盐的甜菜汁或酸盐贫乏的安慰剂.
主要成果:
- 与安慰剂相比,富含酸盐的甜菜汁显著改善了耐力穿行走时间 (30秒差异,p=0.0281).
- 通过流媒体扩张测量出的内皮功能显示显著改善 (+4.73%,p=0.007).
- 平均动脉血压通过酸盐补充剂显著降低 (-3.9 mmHg,p=0.028).
结论:
- 饮食中酸盐补充剂,通过甜菜汁,提供了一个有希望的非药物方法,以提高3组肺高血压的运动能力.
- 改善的内皮功能和降低的血压表明,酸盐补充剂在这个人群中具有更广泛的心血管益处.
- 需要进一步的研究来探索酸盐补充剂在治疗肺高血压方面的长期疗效和更广泛的应用.
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