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Updated: May 28, 2025

Chromosome Replicating Timing Combined with Fluorescent In situ Hybridization
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使用机器学习解开单细胞DNA复制时间动态,揭示了癌症进展的异质性

Joseph M Josephides1, Chun-Long Chen2

  • 1Institut Curie, PSL Research University, CNRS UMR3244, Dynamics of Genetic Information, Sorbonne Université, Paris, France.

Nature communications
|February 8, 2025
PubMed
概括

我们开发了MnM,这是一种机器学习工具,用于分析异质癌症样本中的单细胞复制时间 (scRT). MnM揭示了基因组异质性和染色体异常,提供了对瘤发生和DNA复制动态的见解.

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