先进的糖化终产品和肝硬化患者的死亡风险:一个前性队列研究
Mohsen Shaygan Tabar1,2, Maryam Nilghaz2, Azita Hekmatdoost2
1Student Research Committee, Department of Clinical Nutrition and dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Scientific reports
|February 8, 2025
概括
饮食中的高级糖化终产品 (AGEs) 与肝硬化患者的死亡风险增加有关. 较高的AGE摄入量与5年死亡人数的显著增加有关.
科学领域:
- 肝病学和营养科学 肝病学和营养科学
- 临床研究 临床研究
- 公共卫生 公共卫生
背景情况:
- 饮食在控制肝病和肝硬化相关死亡率方面发挥着至关重要的作用.
- 先进的糖化终产物 (AGEs) 是体内或饮食中形成的化合物,可能影响健康结果.
- 饮食中AGE对肝硬化患者死亡风险的具体影响需要进一步调查.
研究的目的:
- 调查晚期糖化终产品 (AGEs) 的饮食摄入量与被诊断为肝硬化患者的死亡率之间的关联.
- 量化与不同水平的饮食AGE消费相关的死亡风险.
主要方法:
- 一项前性队列研究对166名在6个月内被诊断患有肝硬化的门诊患者进行了研究.
- 患者被跟踪了五年,以记录死亡事件.
- 调整了各种混因子的考克斯回归模型用于分析饮食AGE四分位数与死亡率之间的关系.
主要成果:
- 根据年龄和性别进行调整的初步分析显示,在AGE四分位数中,死亡风险没有显著增加 (P趋势=0.075).
- 然而,经过额外的混因素的调整后,观察到随着饮食中AGE摄入量增加而增加死亡风险的显著趋势 (P趋势=0.040和P趋势=0.048).
- 死亡人数显著增加,饮食AGE的趋势不断增加 (P = 0.024),这表明与饮食AGE较高相关的死亡风险更高.
结论:
- 晚期糖化终产品 (AGEs) 的较高饮食摄入量与肝硬化患者的死亡风险增加有关.
- 减少AGE消费的饮食修改可能是改善肝硬化患者治疗结果的潜在策略.
- 需要进一步的研究来探索饮食中AGE在肝病进展中的机制和临床影响.
相关概念视频
01:19Overview of Carbohydrate Metabolism
685
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
685
01:15Diabetes: Symptoms, Diagnosis, and Complications
499
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
499
01:05Proteoglycans
3.9K
Glycans, a class of complex heterogeneous molecules, can be covalently attached to proteins to form glycosylated proteins that regulate various physiological and pathological processes. Glycosylated proteins or glycoproteins comprise N-linked and O-linked oligosaccharides. O-glycosylation is the most common type of protein glycosylation. Here, glycans attach to the oxygen atom of the hydroxyl groups of Serine or Threonine residues. O-linked glycosylation occurs later in protein processing,...
3.9K
01:22Diabetes Mellitus: Type 2 and Gestational
2.1K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.1K
01:15Hypoglycemia and Glucagon
149
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
149
01:30Acute Pancreatitis II: Clinical Manifestations and Management
84
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
84