导电血凝度测试用于评估在接受选择性手术的患者处方XA因子抑制剂的凝血活性:一项前性观察性研究
Aya Takemoto1, Nobuyo Kondo1, Akiko Kitajo1
1Department of Anesthesiology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
Thrombosis research
|February 9, 2025
概括
电流血凝度计 (DBCM) 有效地测量了XA因子抑制剂的抗凝作用. 这种临床检测与药物度和血栓生成有很好的相关性,在临床环境中证明有用.
科学领域:
- 临床化学 临床化学
- 血液学 血液学 血液学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 介电血凝度计 (DBCM) 是一种利用介电电容性的新型凝血试验.
- 开发了一种新的DBCM盒子,以评估XA因子抑制剂的抗凝效应.
- 这项研究证实了该系统在接受选择性手术的患者中的临床实用性.
研究的目的:
- 评估DBCM测量的凝血时间与XA因子抑制剂的血度之间的关系.
- 评估DBCM凝血时间和峰值血栓生成之间的相关性.
- 为了确定DBCM在检测XA抑制因子活性方面的诊断性能.
主要方法:
- 在术前和术后进行全血样本采集.
- 使用DBCM弹测量凝血时间.
- 对血样本进行了血栓生成和体外Xa因子抑制剂定量分析.
- 使用了斯皮尔曼相关性和ROC曲线分析.
主要成果:
- DBCM凝血时间与血阿皮克萨班 (Rs=0.87) 和里瓦罗克萨班 (Rs=0.91) 度有很强的相关性.
- 在DBCM时间和峰值血栓生成之间观察到显著的相关性 (阿皮克萨班Rs=-0.80,里瓦罗克萨班Rs=-0.84).
- 在ROC分析中,XA因子抑制剂度低于30ng/mL (AUC0.98-0.99) 的高诊断性能得到证明.
结论:
- 介电血凝度测试作为监测XA抑制剂抗凝的有价值的临床检测.
- DBCM系统准确地反映了这些药物诱导的抗凝固状态.
- 这项技术为服用XA抑制剂的患者的临床管理提供了一个实用的工具.
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