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双的环境污染:从塑料生产到实验模型中的肠道形态生理学调节

Beatriz Gouvêa de Luca¹, Patricia Pereira Almeida², Reinaldo Röpke Junior³

¹Research Center on Morphology and Metabolism, Biomedical Institute, Federal Fluminense University, Niteroi, RJ, Brazil; Laboratory of Teaching and Research in Histology and Comparative Embryology (LEPHEC), Federal Fluminense University, Niterói, RJ, Brazil; Pathology Graduate Program, Federal Fluminense University (UFF), Niteroi, RJ, Brazil.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

|February 9, 2025

概括

在塑料中常见的双暴露会通过减少微生物多样性和破坏肠道屏障来破坏肠道. 围产期暴露会导致显著的肠道炎症和透性变化.

科学领域:

环境健康环境健康
毒理学毒理学毒理学
胃肠病学胃肠病学

背景情况:

双是塑料中发现的内分泌干扰剂,与肥胖和糖尿病有关.
环境的存在和慢性疾病的关联导致使用限制.
胃肠道是一个关键的吸收部位,易受双醇的影响.

研究的目的:

审查对双暴露和对肠道有害影响的研究.
研究对肠道微生物群,形态,透性和肠道神经系统的影响.
包括围产期和成人实验模型.

主要方法:

对检查双暴露的研究进行文献综述.
对各种胃肠道参数的影响的分析.
包括来自围产期和成人实验模型的数据.

主要成果:

双暴露通常会降低肠道微生物的多样性.
肠道屏障的完整性受到损害,导致炎症.
周产期暴露导致结肠炎症增加和透性改变.

结论:

双暴露对肠道微生物群和屏障功能产生负面影响.
副作用包括炎症,形态变化和透性的改变.
周产期暴露对肠道发育和健康构成重大风险.

关键词:

双二醇 (Bisphenol) 是一种二醇.肠道神经系统肠道神经系统我们的肠道微生物群.炎症炎症是一种炎症.肠道屏障肠道屏障肠道屏障肠道的透性肠道的透性

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