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卵巢组织冷保存后的怀孕结果:澳大利亚队列研究

Tara Finkelstein¹, Daniel Lorber Rolnik², Franca Agresta³

¹Department of Obstetrics and Gynaecology, Monash University, Melbourne, Australia.

American journal of obstetrics and gynecology

|February 9, 2025

概括

卵巢组织冷保存提供了一种可行的生育保护选择,大约五分之一的女性在手术后怀孕. 这项研究证实了其在澳大利亚未来生育咨询的临床可行性.

科学领域:

生殖医学生殖医学
在瘤学瘤学.
妇科妇科医生妇科

背景情况:

卵巢组织冷保存是年轻女性的一个关键的生育保存方法,在欧洲和澳大利亚广泛使用.
这种技术在澳大利亚的临床周产期结局在很大程度上仍未得到证实.
了解这些结果对于全球患者益处评估至关重要.

研究的目的:

评估在维多利亚州 (澳大利亚) 进行卵巢组织冷保存和移植后的妊娠和死亡结果.
在这个群体中确定成功生育结果的预测因素.
为了解卵巢组织冷保存功效作出贡献.

主要方法:

一项回顾性队列研究分析了593名接受卵巢组织冷保存 (1995年7月至2022年7月) 的患者.
进行了与维多利亚周产期数据收集和出生死亡和婚姻数据库的数据链接.
对于18岁以上的患者,收集了怀孕和死亡率数据.

主要成果:

从114名妇女中报告了192名新生儿,移植 (25.0%) 和非移植 (18.7%) 组之间的怀孕率相似.
总体而言,17.9%的患者死于他们潜在的疾病.
在冷保存后的15年内报告有怀孕,这表明长期可行性.

结论:

这项澳大利亚大型单中心研究证明了卵巢组织冷保存的临床可行性.
五分之一的女性怀孕,突出其价值作为一种生育保护选择.
研究结果支持对卵巢组织进行冷保存,以便在未来进行生育咨询.

关键词:

保护生育能力保护生育能力活生生的出生是活生生的出生.卵巢组织的冷保存.卵巢组织移植移植围产期的结果.怀孕怀孕怀孕怀孕怀孕

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