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患有精神疾病的患者的口腔菌群:对组成和功能变化的范围审查
Mauro Scala1, María Del Rocío González Soltero2, Alberto Bellido Esteban3
1Department of Biomedical and Neuromotor Sciences (DIBINEM), Alma Mater Studiorum-University of Bologna, Italy; Health Research Institute Hospital 12 de Octubre, (imas12), Madrid, Spain; Faculty of Biomedical and Health Sciences, European University of Madrid (UEM), Madrid, Spain; Complutense University of Madrid (UCM), Madrid, Spain.
Progress in neuro-psychopharmacology & biological psychiatry
|February 9, 2025
概括
嘴细菌如Lactobacillus gasseri和硫化生产者可能表明精神疾病. 改变的口腔微生物群落与精神病发病和进展有关.
科学领域:
- 微生物学 微生物学
- 精神病学是一个精神病学.
- 人类微生物组 人类微生物组
背景情况:
- 口腔膜微生物群的变化越来越多地与精神疾病的发展和进展有关.
- 了解这些微生物变化对于识别潜在的生物标志物和治疗点至关重要.
研究的目的:
- 在患有精神疾病的患者中进行范围审查,绘制口腔菌群组成,多样性和功能的证据.
- 包括临床高危精神病 (CHRP) 个体和经历第一发精神病 (FEP) 的人.
主要方法:
- 系统的文献搜索使用PubMed,科学网络和CINAHL数据库进行,直到2024年2月.
- 遵守PRISMA-ScR综合范围审查方法检查清单.
主要成果:
- 分析了7项涉及315名参与者的横截面研究.
- 在精神分裂症,CHR-P和FES中观察到增加的Lactobacillus gasseri和Firmicutes/Proteobacteria比率.
- 变化的微生物多样性和代谢途径 (氨基酸,碳水化合物,异生菌) 已注意到,富含硫化生产细菌.
结论:
- 乳酸菌和生产硫化的细菌在精神疾病中代表了潜在的口腔大微生物特征.
- 口腔菌群的组成和功能与精神病的各个阶段有关,CHR-P和FES之间存在重叠.
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