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对抗SARS-CoV-2的宿主向抗病毒药物在临床开发中-前景还是失望?

André Schreiber¹, Stephan Ludwig¹

¹Institute of Virology Muenster, University of Muenster, Muenster, Germany.

Antiviral research

|February 9, 2025

概括

针对宿主的抗病毒药物 (HTA) 对SARS-CoV-2有希望,但在临床进展方面面临挑战. 本审查审查了先进试验中的HTA,其开发障碍和监管途径.

科学领域:

病毒学病毒学
免疫学免疫学免疫学
药理学药理学是指药理学的学科.

背景情况:

随着COVID-19的流行,迅速发展抗病毒疗法.
传统的直接作用抗病毒药物 (DAA) 向病毒组件.
针对宿主的抗病毒药物 (HTA) 通过调节宿主途径或免疫反应提供了替代方案.

研究的目的:

审查已经达到 2-4 期临床试验的针对 SARS-CoV-2 的宿主向抗病毒药物 (HTA).
探索HTA开发,监管批准和市场准入方面的挑战.

主要方法:

科学出版物和临床试验数据库的文献综述.
对针对SARS-CoV-2的HTA研究的分析.
审查监管途径和发展障碍.

主要成果:

许多HTA在体外和体内表现出针对SARS-CoV-2的潜力.
有限数量的HTA已经进入后期临床试验 (2-4期).
显著的挑战阻碍了HTA向临床实践和市场批准的进展.

结论:

HTA代表了COVID-19的一个有前途的治疗策略.
克服开发和监管挑战对于HTA成功至关重要.
需要进一步的研究和战略规划,才能为患者提供有效的HTA.

关键词:

在 COVID-19 疫情中,药物重新定位是药物重新定位.针对宿主的抗病毒药物这就是SARS-CoV-2病毒.治疗策略治疗策略病毒与主机的互动

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