舒安白莲混合物通过调节PI3K-Akt-Bcl 2信号通路来增强西斯的抗癌作用
Yilin Zheng1, Xiaoyan Li2, Guohai Huang3
1Clinical Research Center, Shantou Key Laboratory of Basic and Translational Research of Malignant Tumor, Shantou Central Hospital, Shantou, China.
Journal of ethnopharmacology
|February 9, 2025
概括
舒安白莲混合物 (SBLM) 通过抑制PI3K/Akt/Bcl-2通路,促进细胞亡,增强食道癌的西斯普拉丁化疗. 这种组合疗法在减少瘤大小和提高治疗疗效方面表现有前途.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 传统中国医药 传统中国医药
背景情况:
- 食道癌 (EC) 由于预后不佳和死亡率高,因此具有重大临床挑战.
- 锡斯普拉丁 (CP) 的耐药性限制了其作为EC的第一线化疗的有效性.
- 传统中医药,如Shuang Bailian混合物 (SBLM),被探索作为化学疗法的辅助.
研究的目的:
- 阐明SBLM增强CP的抗癌作用的机制.
- 为了确定SBLM的分子标,与CP疗法结合使用.
主要方法:
- 网络药理学和分子对接确定了SBLM的潜在目标.
- 在体外测试 (CCK-8,伤口愈合,殖民地形成,流动细胞计,西部涂抹) 评估了SBLM对癌细胞的影响.
- 在裸体小鼠中使用瘤异种移植模型的体内研究评估了联合治疗潜力.
主要成果:
- 网络药理学确定PI3K-Akt-Bcl-2信号通路是SBLM的一个关键目标.
- 通过抑制增殖,殖民地形成和入侵,SBLM显著增强了CP的抗癌活性,同时诱导了细胞亡和细胞循环停止.
- 与单个治疗相比,SBLM + CP联合治疗在体内显著减少了瘤大小.
结论:
- 通过抑制PI3K/Akt/Bcl-2通路,SBLM增强了对EC的CP疗效,从而诱导癌细胞亡.
- SBLM显示出作为一种有价值的辅助疗法的潜力,以改善食道癌的化疗方案.
相关概念视频
01:45Positive Regulator Molecules
105.7K
To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.
105.7K
02:57Targeted Cancer Therapies
7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.4K
02:50Combination Therapies and Personalized Medicine
4.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.8K
01:15Drugs that Stabilize Microtubules
2.0K
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.0K
01:31The Intrinsic Apoptotic Pathway
6.1K
Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
6.1K