疑似在一匹马中发生的二中毒
B P Simões1, F M Cerri1, R K Takahira1
1Veterinary Clinic Department, School of Veterinary Medicine and Animal Science (FMVZ), Sao Paulo State University (UNESP), Professor Doctor Walter Mauricio Correa Street, unnumbered, Botucatu São Paulo, Brazil, 18618-681.
Journal of equine veterinary science
|February 9, 2025
概括
马匹意外中毒芬农药可能会导致严重的症状,如出汗和呼吸困难. 及时的支持性护理,包括液体和降低发烧,导致治疗的四分之一马完全康复.
科学领域:
- 兽医毒理学 兽医毒理学
- 马类医学 马类医学
- 杀虫剂安全性 杀虫剂安全性
背景情况:
- хлорфенапир是一种亲昆虫杀药,可以解离氧化酸化,导致线粒体功能障碍和细胞死亡.
- 虽然在人类和狗身上有记录,但在马群中二中毒的情况不太常见,这给马群带来了独特的临床挑战.
- 意外暴露可能发生在受污染的牧场上,对马的健康构成风险.
研究的目的:
- 记录一匹疑似有费纳皮尔中毒的马的临床表现和实验室发现.
- 描述诊断方法和成功的支持性治疗芬阿皮尔中毒在马患者.
- 为了突出农药使用在马经常出行的地区的潜在风险.
主要方法:
- 一份病例报告显示,一个4岁的四分之一马马在最近喷的牧场里放牧后出现了急性临床症状.
- 临床检查包括对生命体征,神经状况的评估,以及对农药毒性的特征症状的观察.
- 实验室分析涉及血清生物化学,以评估器官功能,特别是脏和肝脏的情况.
主要成果:
- 这匹马表现出过度出汗,高热,短睡,肌肉结和神经症状.
- 最初的血清生物化学检测显示,和肝功能异常.
- 马对支持性护理产生了积极的反应,包括静脉注射液体治疗,抗炎药物 (二) 和水疗.
结论:
- 在潜在暴露后呈现急性全身症状的马匹中,应考虑芬阿皮尔中毒.
- 支持性护理,重点是液体治疗,发烧管理和症状治疗,可以有效地管理马匹的费纳皮尔中毒.
- 这一案例强调了谨慎使用农药和牧场管理的重要性,以防止意外的马类中毒.
更多相关视频
相关概念视频
Physical Properties of Amines
3.2K
Amines with low molecular weight are usually gaseous at room temperature, while those with high molecular weight are liquid or solids in nature. Usually, low molecular weight amines have a rotten fish-like smell. Diamines typically have a pungent smell. For instance, cadaverine and putrescine, depicted in Figure 1, are two molecules responsible for decaying tissue.
3.2K
Prevention of Further Absorption of Poison
1.4K
In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
1.4K
Anticholinesterase Agents: Poisoning and Treatment
2.0K
Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
2.0K
Toxicity Testing in Animals
204
Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
204
Pharmaceutical Poisoning: Potential Scenarios
116
Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
116
Pharmaceutical Poisoning: Treatment Strategies
279
Treatment strategies for poisoning are a critical aspect of emergency medicine, focusing on preventing the absorption of toxins and enhancing their elimination. When a poisoning incident occurs, the first response is to halt exposure and decontaminate the patient, particularly through gastrointestinal (GI) methods if the poison was ingested.Gastrointestinal Decontamination Techniques:Activated charcoal is the cornerstone of GI decontamination. It works through adsorption, binding the toxin to...
279


