欧洲骨髓瘤网络小组关于原发性血细胞白血病的审查和共识声明
P Musto1, M Engelhardt2, N W C J van de Donk3
1Department of Precision and Regenerative Medicine and Ionian Area, "Aldo Moro" University School of Medicine, Bari, Italy; Hematology and Stem Cell Transplantation Unit, AOU Consorziale Policlinico, Bari, Italy.
概括
初级血细胞白血病 (PPCL) 仍然具有侵略性,仍然需要改善生存率. 欧洲骨髓瘤网络为PPCL管理提供了最新的指导方针和建议,强调临床试验以获得更好的结果.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 血细胞疾病 血细胞疾病
背景情况:
- 初级血细胞白血病 (PPCL) 是一种具有攻击性的血细胞恶性瘤.
- 与多发性骨髓瘤相比,目前PPCL的生存率不令人满意.
- 国际骨髓瘤工作组已经制定了PPCL的新诊断标准.
研究的目的:
- 为了提供PPCL管理的最新概述.
- 建立基于共识的PPCL治疗建议.
- 确定改善患者治疗结果的未来前景.
主要方法:
- 欧洲骨髓瘤网络 (EMN) 专家小组审查了最近的文献.
- 与PPCL管理相关的关键问题被生成并排名.
- 在使用德尔菲问卷方法实现了对建议的共识,至少80%的同意.
主要成果:
- 介绍了PPCL的生物学,临床,预后和治疗方面的概述.
- 提供了更新的PPCL管理指南和实际建议.
- 包括有关正在进行和即将进行的临床试验的信息.
结论:
- 然而,PPCL仍然是一个未满足的临床需求.
- 最近在PPCL管理方面取得了进展.
- 该EMN小组支持正在进行的临床试验和生物研究,以寻找PPCL治疗的突破.
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