对长期发生的脑膜炎球菌流行病的植物动力学分析揭示了多次引入和流行前扩张
Zuyu Yang1, Heather Davies1, Jane Clapham1
1Institute of Environmental Science and Research, Porirua, New Zealand.
概括
新西兰 (NZ) 的脑膜炎菌 (IMD) 有着复杂的历史. 植物动力学分析显示,NZMenB菌株在流行病之前产生和扩大,可能与社会因素有关.
科学领域:
- 微生物学 微生物学
- 流行病学 流行病学
- 基因组学就是基因组学.
背景情况:
- 尼塞利亚脑膜炎导致侵袭性脑膜炎球菌病 (IMD),导致全球爆发.
- 澳大利亚/新西兰 (NZ) 从1991年至2008年面临着长期的超流行性B组IMD爆发 (NZMenB).
- 特定株 (cc41/44,PorA P1.7-2.4),NZMenB仍然导致了新西兰B组病例的很大一部分.
研究的目的:
- 调查NZMenB流行病菌株的起源和发病原因.
- 了解NZMenB的进化历史和人口动态.
- 探索NZMenB流行病的潜在社会触发因素.
主要方法:
- 几乎所有NZMenB分离物的植物动力学分析 (1990-2019).
- 分子约会和克隆扩张分析.
- 将NZMenB分离物与国际脑膜炎球菌数据进行比较.
主要成果:
- NZMenB包括三个不同的分类 (分类41,分类154,分类42) 具有独特的起源和扩张模式.
- 有证据表明,NZMenB在公认的流行病时期之前已经传播和扩大.
- 观察到多次引入和重新引入新西兰,国际相关性有限.
结论:
- 流行性NZMenB菌株具有复杂的进化历史,早于疫情爆发.
- 社会因素,包括增加的不平等和政府政策造成的家庭拥挤,被认为是疫情的潜在触发因素.
- 进一步研究社会因素和传染病动态的相互作用是有必要的.
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