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机械洞察力突变的质子合叶酸载体 (SLC46A1) 导致遗传性叶酸吸收不良

Prithviraj Nandigrami1, I David Goldman2, Andras Fiser1

  • 1Departments of Systems & Computational Biology, Albert Einstein College of Medicine, Bronx, New York, USA; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA.

The Journal of biological chemistry
|February 9, 2025
PubMed
概括

遗传性叶酸吸收不良 (HFM) 是由于质子合叶酸载体 (PCFT) 的突变造成的. 分子模拟显示,这些突变破坏PCFT结构,损害叶酸运输并引起疾病.

关键词:
在PCFTFT中,我们可以使用PCFT.在 SLC46A1 中.遗传性叶酸吸收不良的原因灭活和补偿突变的发生.分子动力学模拟,分子动力学模拟

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