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和多基基物质与腹部脂肪分布之间的关联:特征光谱暴露模式和基于结构的调查

Zhi Li¹, Shi Lin Shan¹, Chen Yang Song¹

¹State Key Laboratory of Reproductive Medicine, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, Jiangsu, China;Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 211166, Jiangsu, China.

Biomedical and environmental sciences : BES

|February 9, 2025

概括

血清中和多醇基物质 (PFAS) 的暴露与区域脂肪分布有关,其影响因年龄,性别和PFAS结构而异. 一个高度准确的预测模型可以评估PFAS暴露的肥胖风险.

科学领域:

环境健康环境健康
毒理学毒理学毒理学
人类健康人类健康人类健康

背景情况:

和多基基物质 (PFAS) 是广泛使用的合成化学品,对环境和健康的担忧越来越大.
了解PFAS暴露与人体成分之间的关系对于公共卫生至关重要.
区域脂肪分布在代谢健康和疾病风险方面发挥着重要作用.

研究的目的:

调查8种血清PFAS与区域脂肪库之间的关联.
探索PFAS暴露如何影响基于年龄,性别和化学结构的脂肪分布.
开发一种与PFAS暴露相关的肥胖风险的预测模型.

主要方法:

从2011-2018年国家健康和营养检查调查 (NHANES) 的数据分析.
利用多个线性回归模型来评估血清PFAS度和六种脂肪成分之间的关联.
开发了一个预测模型来估计PFAS暴露的预测肥胖风险的能力,计算AUC.

主要成果:

在39-59岁的女性中,干部脂肪质量与 perfluorooctane sulfonate (PFOS) 有积极的关联.
某些PFAS (PFOS,PFHxS,PFDeA,PFNA,n-PFOA) 的较高水平与女性内脏脂肪组织的增加有关.
在男性中,全链和长链PFAS与腹部脂肪减少有关,而短链PFAS与39-59岁女性腹部脂肪增加有关.

结论:

暴露于PFAS显然与区域脂肪分布有关,在年龄,性别和PFAS化学结构上观察到差异性影响.
这些发现强调了PFAS对脂肪积累和肥胖风险的潜在影响,这对公共卫生有重大影响.
为评估与PFAS暴露相关的肥胖风险,开发了一种高度准确的预测模型 (AUC为0.9925).

关键词:

尼汉斯 (NHANES) 是一个名人.肥胖问题肥胖问题和多醇基物质是多和多的.区域脂肪仓库的地区脂肪仓库.基于结构的基于结构的.

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