在不同预测风险人群中,鱼类消费与中风发生率之间的关联:来自中国的前性队列研究
Hong Yue Hu1, Fang Chao Liu2, Ke Yong Huang2
1Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, Jiangsu, China;Department of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
Biomedical and environmental sciences : BES
|February 9, 2025
概括
较高的鱼类消费显著降低了中风风险,特别是对于预测中风风险中等至高的人来说. 这种饮食模式为那些面临更高风险的人提供了更大的保护.
科学领域:
- 心血管流行病学心血管流行病学
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 饮食鱼类摄入量与中风风险之间的关联仍在争论中.
- 现有研究尚未一致澄清这种关系是否基于个体预测的中风风险而有所不同.
- 了解这些细微差别对于有针对性的公共卫生建议至关重要.
研究的目的:
- 为了调查鱼类消费和意外中风之间的关联.
- 为了确定这种关联是否受到预测中风风险类别的修改.
- 量化鱼类摄入量与中风风险之间的相互作用.
主要方法:
- 来自"预测中国动脉样硬化心血管疾病风险" (CVD风险在中国) 项目的大型队列研究 (95,800名参与者).
- 通过标准化调查问卷收集的鱼类消费数据.
- 考克斯的比例危险模型用于估计危险比率 (HRs) 和95%信心区间 (CI),使用相对过度风险因相互作用 (RERI),归因比例 (AP) 和协同作用指数 (SI) 评估添加性相互作用.
主要成果:
- 在703,869人年中,记录了2,773次中风事件.
- 较高的鱼类消费与中风风险降低相关 (HR=0.64,95% CI:0.49-0.85对于低风险;HR=0.53,95% CI:0.47-0.60对于中等至高风险).
- 在鱼类消费和预测中风风险之间观察到显著的添加相互作用 (RERI=4.08,SI=1.64,AP=0.36).
结论:
- 增加鱼类消费与中风发病率较低有关.
- 鱼类消费的保护作用在被归类为中风风险中等至高的人群中更为明显.
- 研究结果表明,较高的鱼类摄入量对预防中风有潜在的益处,特别是在高风险人群中.
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